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Poly (ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation.

Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

Concanavalin A, ribose, and adenine resuscitate preserved rat hearts.

A comparison of different carbohydrates as substrates for the isolated working heart.

Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model.

The role of ribose in human skeletal muscle metabolism.

The benefits of ribose in cardiovascular disease.

Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: studies in normal and hypertrophied hearts.





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Title: The benefits of ribose in cardiovascular disease.

Author(s): Pauly DF, Johnson C, St Cyr JA.

Source: Med Hypotheses. 2003 Feb;60(2):149-51.

Content: Division of Cardiology, University of Florida, Gainesville, Florida, USA. Cardiovascular disease still ranks as the leading cause of death in men and women. Adults have tried to lower their risk of cardiovascular disease by improving their diet, quitting smoking, controlling blood pressure and exercising regularly. Additionally, many adults have turned to nutriceutical or natural products. Myocardial ischemia, produces a depression in myocardial tissue levels of high energy compounds, along with a compromise in myocardial function. Ribose, a naturally occurring sugar, has been extensively investigated, both in animal and clinical studies, as an agent to enhance the recovery of these depressed energy compounds. Results of these studies have been promising in enhancing the recovery of these energy molecules along with an improvement in myocardial function. Therefore, ribose should be considered as a potential agent in the treatment of ischemic cardiovascular disease.

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Many studies reported herein have been performed on laboratory animals and not on humans. While some results of animal trials are later found to be similar in human trials, we have no way of knowing whether or not this will be the case.

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